THE MOVEMENT OF ELECTROLYTES AND OF WATER IN SURVIVING TISSUE OF THE LIVER

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Abstract
When liver slices immediately after their removal from the body are immersed in graded solutions of NaCl, movement of water does not follow a course determined by movement of Na ions. From hypotonic solutions Na enters slowly and swelling proceeds rapidly but with increasing concentration entrance of sodium increases and swelling diminishes in accord with the osmotic relations between tissue and the medium. The extracellular fluid of liver has the same osmotic pressure as blood plasma, and entrance of water into liver slices from media with greater molar concentration is determined by the intracellular pressure of the parenchymatous cells of the tissue. When KC1 is added to the Krebs-Ringer solution so that its potassium content has been increased 10-fold the water intake of liver cells has not varied in accord with the K content of the medium. Movement of water between cells and extracellular fluid may occur independently of changes in the Na or of K content of cells and doubtless is in part determined by substances associated with metabolism.

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