Effect of Nifedipine on Frequency-Force Relationship in Isolated Dog Left Ventricular Muscle.
Open Access
- 1 January 1978
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 28 (5) , 783-785
- https://doi.org/10.1254/jjp.28.783
Abstract
Nifedipine is a highly potent Ca2+-antagonistic inhibitor of excitation-contraction coupling. Nifedipine showed greater depression of developed tension at higher frequencies in the isolated, blood-perfused canine left ventricle. The mode of action of nifedipine on the myocardium may be similar to that of verapamil but differs from that of manganese chloride, pentobarbital, Ni2+ or La3+.This publication has 5 references indexed in Scilit:
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- Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth MuscleAnnual Review of Pharmacology and Toxicology, 1977
- Effect of Verapamil on Frequency-Force Relationship in Isolated Dog Left Ventricular MuscleThe Japanese Journal of Pharmacology, 1977
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