EVALUATION OF THE COMBINED EFFECTS OF ATROPINE AND NEOSTIGMINE ON THE LOWER OESOPHAGEAL SPHINCTER
- 1 July 1985
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 57 (10) , 956-959
- https://doi.org/10.1093/bja/57.10.956
Abstract
The effects, on the lower oesophageal sphincter, of the simultaneous administration of atropine and neostigmine were studied in 10 healthy patients undergoing gynaecological surgery. Atropine 1.2 mg and neostigmine 2.5 mg were given to antagonize neuromuscular blockade at the termination of surgery. For the succeeding 15-20 min, frequent measurements of lower oesophageal sphincter pressure (LOSP) were made while anaesthesia was maintained. It was demonstrated that this drug combination resulted in a significant decrease in LOSP initially, but that this potentially deleterious effect was transient in nature.This publication has 4 references indexed in Scilit:
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