5-Methyltetrahydrofolic Acid Is Not a Methyl Donor for Biogenic Amines: Enzymatic Formation of Formaldehyde
- 17 January 1975
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 187 (4172) , 171-173
- https://doi.org/10.1126/science.1111095
Abstract
Contrary to previous reports, 5-methyltetrahydrofolic acid does not mediate the methylation of dopamine to epinine. Instead, this methyl donor is degraded enzymatically to formaldehyde, which condenses with dopamine to form a tetahydoisoquinoline derivative. The latter has chromotographic characteristics very similar to those of epinine, which likely accounts for the original misidentification of the product.Keywords
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