The Growth-Stimulating Effect of Biotin for the Diphtheria Bacillus in the Absence of Pimelic Acid

Abstract
The stimulation of growth of the Allen strain diphtheria bacillus by biotin in the absence of pimelic acid as compared with stimulation by pimelic acid suggests that the pimelic acid is used for the synthesis of biotin. Pimelic acid cannot replace biotin in its growth-stimulating effect on yeast. These findings suggest that pimelic acid may be a factor in biotin synthesis by bacteria in the intestinal tract.

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