Brain and behavioral effects of dietary n‐3 deficiency in mice: A three generational study

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Abstract
Feeding mice a diet deficient in n‐3 fatty acids for three generations resulted in a 53% decrease in docosahexaenoic acid (DHA, 22 : 6n‐3) in the brain. Maternal pup retrieval and social learning of a food preference are both tasks based on olfactory function. All dams made contact more readily with pups of their own dietary group, and animals of both dietary groups demonstrated the ability to learn a food preference through exposure to a conspecific that had previously eaten the food. Both groups showed similar ability to learn the location of the hidden platform in the Morris water maze, while the n‐3 deficient animals were marginally faster in locating the platform on the cued trial. They were also more active when tested in the open field. While they did not differ in their duration of immobility in a forced swimming test, the deficient animals did have longer paw‐lick latencies on a hot plate. Thus, in this study a significant reduction in brain n‐3 fatty acid composition, while associated with some indications of change in emotional reactivity, did not impair olfactory function or learning of either a latent or spatial nature.©1994 John Wiley & Sons, Inc.