Autoreactive or self restricted?

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Abstract
Putative major histocompatibility complex (MHC) class II‐specific T cell clones were isolated from nominal antigen‐primed T cell populations propagated in vitro under antigen selection. However, unlike the proliferative responses of nominal antigen‐specific, MHC class II‐restricted T cell clones derived from the same population, the former's MHC‐specific proliferative responses required that the culture medium be supplemented with serum. The role of xenogeneic antigens in the generation of this category of “autoreactive” T cells is discussed.