SERUM VITAMIN A AND TOTAL PLASMA LIPID CONCENTRATIONS AS INFLUENCED BY THE ORAL ADMINISTRATION OF VITAMIN A TO CHILDREN WITH THE NEPHROTIC SYNDROME 1

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Abstract
This study demonstrated that there is an abnormality in the metabolism of vit. A in children with the nephrotic syndrome. Although higher serum vit. A concns. were observed in patients with higher total plasma lipid concns., no quantitative relationship was demonstrated. Higher serum vit. A levels were found in nephrotic patients following a test dose of vit. A alcohol in aqueous dispersion than following a test dose of vit. A ester in oil. The highest concns. of serum vit. A were observed 6 hrs. or more after admn. At 6 hrs. the levels were 2-10 times as high as the highest level noted in normal children at the same time interval. Statistical analysis of the data show this finding to be significant. The concns. remained elevated for 24 and even for 48 hrs. Various possible causes for these differences were studied and are discussed. The most likely is that the liver in the nephrotic syndrome fails to utilize or store vit. A as rapidly as in the normal.

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