Female sex hormones suppress development of collagen‐induced arthritis in mice
Open Access
- 1 December 1986
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 29 (12) , 1501-1509
- https://doi.org/10.1002/art.1780291212
Abstract
We have previously reported that male DBA/1 mice are more susceptible to collagen-induced arthritis than are females. Here we report that oophorectomy makes female mice as susceptible to collagen arthritis as are normal males. Induction of collagen-induced arthritis in mice is a T cell-dependent process. The role of female sex hormones in modulating T cell-dependent autoimmune diseases is discussed.This publication has 28 references indexed in Scilit:
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