Synthetic Studies toward Phorboxazole A. Stereoselective Synthesis of the C28−C46 Side Chain Fragment
- 30 August 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (19) , 3023-3026
- https://doi.org/10.1021/ol0063656
Abstract
A stereoselective synthesis of the C28−C46 fragment (3) of phorboxazole A is described. Key advances include an enantioselective allylation to establish the stereochemistry of the tetrahydropyran unit and a useful SmI2-mediated modification of the Barbier reaction of iodomethyloxazole 15 with aldehyde 14.Keywords
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