Pretherapeutic morbidity in the prognostic staging of acute leukemia

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Abstract
To classify the clinical severity of acute leukemia, the degrees of pretherapeutic infection and hemorrhage were used to construct a taxonony containing 3 stages. The stages are associated with survival gradients that are clinically and statistically distinctive in both acute lymphoblastic leukemia and acute nonlymphoblastic leukemia. Median survival ranged from 64.0 mo. for stage 1 to 10.5 mo. for stage 3 in acute lymphoblastic leukemia, and from 7.1 mo. for stage 1 to 1.2 mo. for stage 3 in acute nonlymphoblastic leukemia. The gradients, which persist when other prognostic factors and secular therapeutic changes are taken into account, are more distinctive than those found with other forms of stratification.