Reduced acetylcholine sensitivity in dystrophic mouse myotubes in vitro

1 January 1984

journal article
research article
Published by Wiley in Muscle & Nerve

Vol. 7 (1) , 73-76
https://doi.org/10.1002/mus.880070112

Abstract

Acetylcholine (ACh) sensitivity in cultured myotubes from normal or dystrophic mice was investigated using conventional techniques. Dystrophic multinucleate myotubes were found to be less responsive to the ACh with respect to the control preparation. Such a reduced sensitivity to ACh in dystrophic myotubes was accompanied by a reduced binding to ¹²⁵I‐alpha‐bungarotoxin. The possible biological significance of these results on the muscle disease is discussed.

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