PREFERENTIAL GROWTH OF MAMMARY-TUMORS IN INTACT MAMMARY FATPADS

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 41  (10) , 3863-3867
Abstract
Four transplantable mammary tumors, 3 (66, 410 and 168c isolated from a spontaneously occurring strain BALB/cfC3H [mouse] mammary tumor and 1 (D2) arising from a BALB/c hyperplastic alveolar nodule grew better in mammary fatpads than at s.c. sites. Tumor growth was better (P < 0.05) in intact mammary glands than in cleared mammary fatpads for the D2, 410 and 66 tumors (168cl was not tested). The role of immunity in these differences was investigated using the highly immunogenic 410 tumor. Tumor 410 induced equally effective immunity to subsequent challenge whether it was implanted s.c. or in intact fatpads. In immunized animals Tumor 410 was rejected equally well when the challenge site was intact fatpad as when s.c. Tumor 410 induced immunity after implantation into cleared fatpads and was rejected in immunized animals when the challenge site was the cleared fatpad. No evidence was found that the mammary fatpad is immunologically privileged with respect to tumor transplantation antigens as compared to the s.c. site.