Candidate autoantigens in multiple sclerosis
- 1 June 1999
- journal article
- research article
- Published by SAGE Publications in Multiple Sclerosis Journal
- Vol. 5 (3) , 147-160
- https://doi.org/10.1177/135245859900500303
Abstract
Multiple sclerosis is an inflammatory demyelinating CNS disease of putatively autoimmune origin. Novel models of experimental autoimmune encephalomyelitis (EAE) have demonstrated that T cells specific for various myelin and even nonmyelin proteins are potentially encephalitogenic. The encephalitogenic T cell response directed against different CNS antigens not only determines the lesional topography of CNS inflammation but also the composition of the inflammatory infiltrates. The heterogeneity of the lesional distribution seen in EAE might therefore be useful for the understanding of the various clinical subtypes seen in MS. In this review the possible candidate autoantigens in MS are discussed with special regard to the human T cell and B cell responses against various myelin and nonmyelin proteins.Keywords
This publication has 151 references indexed in Scilit:
- Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse Vβ gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor Vβb and T cell receptor Vβa H‐2b miceEuropean Journal of Immunology, 1996
- Mechanisms of Immune Injury in Multiple SclerosisBrain Pathology, 1996
- In vivo clonal expansion of T lymphocytes specific for an immunodominant N-terminal myelin basic protein epitope in healthy individualsJournal of Neuroimmunology, 1995
- Clonal expansion of myelin basic protein‐reactive T cells in patients with multiple sclerosis: Restricted T cell receptor V gene rearrangements and CDR3 sequenceEuropean Journal of Immunology, 1995
- Biochemical and immunohistochemical studies with specific polyclonal antibodies directed against bovine myelin/oligodendrocyte glycoproteinNeurochemical Research, 1993
- T-cell recognition of myelin basic proteinImmunology Today, 1991
- T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosisNature, 1990
- Developmental profile and differential localization of mRNAs of myelin proteins (MBP and PLP) in oligodendrocytes in the brain and in cultureDevelopmental Brain Research, 1989
- Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesionsActa Neuropathologica, 1988
- Impaired measles virus-specific cytotoxic T cell responses in multiple sclerosis.The Journal of Experimental Medicine, 1985