HUMAN URINARY GONADOTROPHINS

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Abstract
SUMMARY: Urinary gonadotrophins were assayed against HMG 20 A during the menstrual cycle in four subjects by methods believed to measure follicle stimulating hormone (FSH) and total gonadotrophin respectively. The gonadotrophins showed qualitative fluctuation. Three subjects showed maximum levels of total gonadotrophin near the middle of the cycle, and three showed a notably different pattern of excretion of FSH with high values in the first part of the cycle. Gonadotrophins from patients with secondary amenorrhoea showed no qualitative fluctuation, but treatment with stilboestrol apparently caused a rise in excretion of interstitial cell stimulating hormone in three out of nine patients. The results of ninety-eight assays are recorded with fiducial limits and are discussed with reference to the specificity of the methods and the importance of inter-assay errors.