Enzyme-linked immunosorbent assay compared with neutralization tests for evaluation of live mumps vaccines
- 1 January 1984
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 19 (1) , 21-25
- https://doi.org/10.1128/jcm.19.1.21-25.1984
Abstract
Mumps-specific antibody levels before and after vaccination with live mumps vaccines were determined by enzyme-linked immunosorbent assay (ELISA) and neutralization tests. A correlation was found between neutralization titers and optical density in ELISA. However, postvaccination sera from some vaccinees who failed to seroconvert by neutralization contained significant levels of mumps-specific antibody detectable by ELISA. In some of these serum specimens, the antibody directed to the F polypeptide of mumps virus was predominant. Most sera positive in ELISA neutralized mumps virus upon the addition of fresh guinea pig serum to the virus-serum mixture.This publication has 22 references indexed in Scilit:
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