MEIOTROPHIC MUTANTS OF Pasteurella Pestis AND THEIR USE IN THE ELUCIDATION OF NUTRITIONAL REQUIREMENTS

Abstract
During the course of characterizing the natural breaks in the biosynthesis of amino acids by P. pestis and of isolating mutants requiring fewer growth factors than the prototroph (meiotrophic mutants), it became apparent that this procedure of meiotrophic mutant isolation and characterization was of general value in the elucidation of the amino acid requirements of other fastidious heterotrophic microorganisms.