Mutants ofStreptomyces coeruleorubidus impaired in the biosynthesis of daunomycinone glycosides and related metabolites
- 1 July 1978
- journal article
- research article
- Published by Springer Nature in Folia Microbiologica
- Vol. 23 (4) , 255-260
- https://doi.org/10.1007/bf02876678
Abstract
Mutants ofStreptomyces coeruleorubidus, blocked in the biosynthesis of anthracycline antibiotics of the daunomycine complex, were isolated from the production strains after treatment with UV light, γ-radiation, nitrous acid, and after natural selection; according to their different biosynthetic activity the mutants were divided into five phenotypic groups. Mutants of two of these groups produced compounds that had not yet been described inStreptomyces coeruleorubidus (aklavinone, 7-deoxyaklavinone, ζ-rhodomycinone and glycosides of ε-rhodomycinone). The mutants differed from the parent strains and also mutually in morphological characteristics but no direct correlation between these changes and the biosynthetic activity could be observed in most cases.Keywords
This publication has 19 references indexed in Scilit:
- Developmental mutants ofStreptomyces coeruleorubidus, a producer of anthracyclines: Isolation and preliminary characterizationFolia Microbiologica, 1978
- Strain improvement inStreptomyces galilaeus, a producer of anthracycline antibiotics galirubinsFolia Microbiologica, 1977
- Spontaneous and induced variability inStreptomyces nogalater producing nogalamycinFolia Microbiologica, 1977
- Studies on the production of daunomycinonederived glycosides and related metabolites inStreptomyces coeruleorubidus andStreptomyces peucetiusFolia Microbiologica, 1977
- Synthesis of .epsilon.-rhodomycinone glycosidesJournal of Medicinal Chemistry, 1977
- The effect of 5,5- Diethylbarbituric acid on the biosynthesis of anthracyclines inStreptomyces galilaeusFolia Microbiologica, 1977
- AnthracyclinesFolia Microbiologica, 1977
- The study of variability and strain selection inStreptomyces atroolivaceusFolia Microbiologica, 1976
- Production of carminomycin by auxotrophic mutants ofActinomadura carminataJournal of Basic Microbiology, 1975
- Adriamycin, 14‐hydroxydaimomycin, a new antitumor antibiotic from S. Peucetius var. caesiusBiotechnology & Bioengineering, 1969