Experimental Cholelithiasis in the Guinea Pig.

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Abstract
Within one day after the intravenous injection of C14 labeled Klebsiella polysaccharide, cholesterol and pigment precipitate and small firm masses appeared in the gall bladder bile of guinea pigs. No C14 was present in the precipitate and less than 1% of the label from the injected bacterial polysaccharide was excreted in bile in 12 hours; hence the precipitate was not due to the direct physicochemical effect of this polysaccharide. The label in bile underwent a single enterohepatic cycle and some of this label was conjugated with bile acids.