PLATELET-BOUND IGM IN AUTOIMMUNE THROMBOCYTOPENIA

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 61  (1) , 119-124
Abstract
Elevated levels of platelet-bound IgG (PA-IgG) are a feature of autoimmune thrombocytopenia (ATP), but this does not occur in all cases. The role of platelet-bound IgM (PA-IgM) in these patients was investigated by using a quantitative enzyme-linked immunosorbent assay (ELISA). Determinations (45) of PA-IgM and PA-IgG were done on 24 patients with ATP. Elevated levels of PA-IgM were found in 93.3% of the determinations, while PA-IgG was elevated in only 71.7%. In 64.4% of determinations, both were elevated. Elevated PA-IgM or PA-IgG alone occurred in 28.9 and 6.7% of determinations, respectively. The frequent involvement of PA-IgM in ATP was shown; a complex interrelationship exists between the 2 Ig classes in ATP. Some of the possibilities that might explain this interrelationship are discussed.