The Effect of a New Benzodiazepine on the Polygraphically Monitored Sleep of Normal Volunteers
- 1 July 1977
- journal article
- research article
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 17 (7) , 398-401
- https://doi.org/10.1002/j.1552-4604.1977.tb04622.x
Abstract
All-night sleep was polygraphically monitored from 10 normal volunteers who took placebo and 3 dosage levels of a new benzodiazepine hypnotic, SCH 16134 [7-chloro-1-(2,2,2-trifluoroethyl)-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-thione] in a double-blind, crossover design. All dosages of the drug decreased the time to fall asleep, and the (2) highest dosages also decreased interspersed wakefulness. REM [rapid eye movement] sleep was suppressed, but slow-wave sleep was not affected. The subjective quality of sleep was improved by the new hypnotic. One subject reported that he felt lethargic the day after the largest dose.This publication has 6 references indexed in Scilit:
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