Defective Interleukin‐1 Production of Monocytes in Patients with Bladder Cancer

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Abstract
Summary— Patients with advanced malignant neoplasms have a variety of abnormal lymphocyte and monocyte functions. We examined the PHA (phytohaemagglutinin) blastogenic response of lymphocytes and interleukin‐1 (IL‐1) production of monocytes in 40 bladder cancer patients and 16 control subjects. The correlation between the 2 parameters was also studied. The PHA blastogenic response was measured by the incorporation of 3H‐thymidine into lymphocytes. IL‐1 production was assayed by the murine thymocyte 3H‐thymidine incorporation assay. As a result, the PHA blastogenic response and IL‐1 production were significantly lower in the high stage bladder cancer patients compared to the control subjects and low stage patients. However, there was no significant correlation between the 2 parameters. Furthermore, with the addition of indomethacin, IL‐1 production in the control subjects and low stage patients improved to the same degree, but it did not reach the control level in the high stage patients.