Haptoglobin synthesis. II. Cellular localization studies.

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Abstract
Haptoglobin was localized by specific immunofluores-cence in the tissues of dogs during the response to experimental inflammation. Specific fluorescence was found solely in islands of hepatic parenchymal cells and Kupffer cells and in a few macrophage-like cells of the spleen. The parenchymal cells are probably the sites of synthesis of haptoglobin, and the Kupffer cells and splenic cells are involved in catabolism of haptoglobin-hemoglobin complexes or haptoglobin.