Inhibitory effects of polyphenolic catechins from Chinese green tea on HIV reverse transcriptase activity
- 1 June 1994
- journal article
- Published by Springer Nature in Journal of Biomedical Science
- Vol. 1 (3) , 163-166
- https://doi.org/10.1007/bf02253344
Abstract
Three polyphenolic catechins, epigallocatechin (1), epicatechin-3-O-gallate (2) and epigallocatechin-3-O-gallate (3), were isolated from Chinese green tea, Ti-Kaun-Yin(Camellia sinensis) and demonstrated as a new class of human immunodeficiency virus-reverse transcriptase (HIV-RT) inhibitor. The concentrations required for 50% inhibition for the compounds (1), (2) and (3) were 7.80, 0.32 and 0.68 µM, respectively. The polyphenolic catechins with a galloyl group at the 3 position were potent inhibitors of HIV-RT. Kinetic analysis indicated that the polyphenolic catechins were competitive inhibitors with respect to the template-primer (rA)n(dT)12–18 and noncompetitive inhibitors to dTTP.Keywords
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