Effect of insulin on the growth of a human hepatoma cell line PLC/PRF/5: A possible role of insulin receptor.
- 1 January 1988
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 156 (4) , 351-357
- https://doi.org/10.1620/tjem.156.351
Abstract
Insulin produced increases in cell number, DNA synthesis and alpha-fetoprotein secretion of a human hepatoma cell line PLC/PRF/5. The insulin-treated cells showed a decrease in binding of 125I-insulin. The decreased binding was due to the decreased numbers as well as the low affinity constant of insulin receptor. These data suggest that insulin is a growth factor for the human hepatoma cells and that insulin receptor plays a role in the growth-promoting effect of insulin.This publication has 8 references indexed in Scilit:
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