INSULIN AND GLUCAGON RECEPTORS IN MORRIS HEPATOMAS OF VARYING GROWTH-RATES
- 1 January 1979
- journal article
- research article
- Vol. 39 (5) , 1443-1446
Abstract
The binding of both insulin and glucagon to receptors in plasma membranes from 5 [rat] hepatomas of varying growth rates [Morris hepatomas 9618A, 9633, 7787, 7288C and 3924A] was diminished when compared to plasma membranes from normal liver. Scatchard analyses of the binding data suggested that the decrease in glucagon binding was due to a decrease in binding capacity, whereas the decrease in insulin binding was due either to a decrease in binding affinity or to site-site interactions. The decreased binding of insulin, but not of glucagon, showed a significant correlation with increasing growth rate of the tumors. Decreased binding of insulin to receptors could be a feature of increasing growth rate in hepatomas.This publication has 11 references indexed in Scilit:
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