Age- and sex-dependent variations of essential metal levels in tissues and responses to dextran sulfate treatment which induces zinc-thionein.

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Abstract
Age and sex dependencies of Fe, Ca and Zn levels in liver, kidney and spleen were investigated in male and female mice (3-12 wk old). To clarify the age and sex dependencies of responses to dextran sulfate treatment, 4 and 12 wk old mice were injected i.p. with dextran sulfate and killed 24 h later. The most striking change was observed in splenic Fe level. The level increased with age and a 5(male)- or 8(female)-fold increase was observed within the experimental period. Dextran sulfate treatment produced a marked decrease of the splenic Fe level and the response was larger in 12 wk old mice. The alterations of metal levels after dextran sulfate treatment in the supernatant and precipitated fractions were also studied.