Droplet-based microfluidics with nonaqueous solvents and solutions

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Abstract
In droplet-based (“digital”) microfluidics, liquid droplets in contact with dielectric surfaces are created, moved, merged and mixed by applying AC or DC potentials across electrodes patterned beneath the dielectric. We show for the first time that it is possible to manipulate droplets of organic solvents, ionic liquids, and aqueous surfactant solutions in air by these mechanisms using only modest voltages (ε*. The threshold for droplet actuation in air with our two-plate device configuration is |ε*| > 8 × 10−11. The mechanistic implications of these results are discussed, along with the greatly expanded range of applications for digital microfluidics that these results suggest are now feasible.