Regulation of Serum 1α,25-Dihydroxyvitamin D 3 by Calcium and Phosphate in the Rat
- 7 November 1975
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 190 (4214) , 578-580
- https://doi.org/10.1126/science.1188357
Abstract
A new radioreceptor assay was used to quantify changes in serum concentration of 1alpha,25-dihydroxyvitamin D3 in rats with low calcium or low phosphate diets. Low availability of either ion elicits a fivefold increase in the circulating concentration of 1alpha,25-dihydroxyvitamin D3. The enhancement of 1alpha,25-dihydroxyvitamin D3 concentration in response to calcium deficiency is dependent on the presence of the parathyroid or thyroid glands (or both), suggesting that this effect is mediated by parathyroid hormone. In contrast, the response of phosphate deficiency is independent of these glands and may result from an action of low serum phosphate concentration or some factor associated with phosphate depletion on the renal synthesis of the 1alpha,25-dihydroxyvitamin D3 hormone.Keywords
This publication has 18 references indexed in Scilit:
- Filter assay for 1α,25-dihydroxyvitamin D3. Utilization of the hormone's target tissue chromatin receptorBiochemistry, 1974
- Radioreceptor Assay for 1α,25-Dihydroxyvitamin D 3Science, 1974
- REGULATION OF VITAMIN-D METABOLISM WITHOUT PARATHYROID HORMONEThe Lancet, 1973
- The Regulation of Vitamin D MetabolismNature, 1973
- Vitamin D3-25-hydroxylase: Tissue occurrence and apparent lack of regulationArchives of Biochemistry and Biophysics, 1973
- Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferolJournal of Clinical Investigation, 1972
- 1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D 3 in the IntestineScience, 1971
- Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestineBiochemistry, 1971
- Unique Biosynthesis by Kidney of a Biologically Active Vitamin D MetaboliteNature, 1970
- Enzymes of protein and phosphate catabolism in rat boneCalcified Tissue International, 1969