Acute Hypertensive Damage of Arterial Vessels of the Heart

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Abstract
Experimentally-induced acute angiotensin hypertension increased the permeability of cardial arteries and arterioles [in rats] to plasma components within a few hours. Only in 1 of the coronary arteries was an increased and focal permeability for plasma components demonstrated, the penetration occurring in the entire thickness of the vessel wall. The permeability observed in intramyocardial small arteries and arterioles showed a distinct deposition of plasma components, both in the tunica intima and the tunica media, and usually in the entire circumference of the vessels. The results support the view that an increased arterial permeability of the myocardial vessels for plasma components is an important initial stage in the development of hypertensive vascular disease of the heart.