EFFECT OF SECONDARY INJECTIONS OF ANTIGEN UPON THE RETENTION IN LIVER OF A PRIMARY INJECTION

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Abstract
The retention of antigen in rabbit liver tissue, resulting from a primary intravenous injection, is influenced by immunization brought about by subsequent intravenous injections of the same antigen. In rabbits given a single primary intravenous injection of radioactive antigen, the retention of radioactivity in liver tissue, after a period of 21 days, was greater than when the primary injection was followed by secondary injections of the same, but non-radioactive antigen. The results were similar for both S35-azohemocyanin and S35-azo-bovine-serum-albumin, except the hemocyanin was retained to a greater extent than the albumin.