The First Silver-Catalyzed Three-Component Coupling of Aldehyde, Alkyne, and Amine
Top Cited Papers
- 18 October 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (23) , 4473-4475
- https://doi.org/10.1021/ol035781y
Abstract
Silver iodide catalyzed the three-component coupling of aldehyde, alkyne, and amines to generate propargylic amines with high efficiency in water. The silver-catalyzed reaction is especially effective for reactions involving aliphatic aldehyde. No additional cocatalyst or activator is required.Keywords
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