EFFECT OF HISTAMINE-H2-RECEPTOR ANTAGONISTS ON EXOCRINE PANCREATIC-SECRETION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 25  (5) , 388-390
Abstract
Pancreatic exocrine secretion was studied in 10 patients with documented duodenal ulcer before and after 4 wk of cimetidine treatment (1 g/day). This chronic short-term cimetidine administration did not result in any substantial modification of exo-pancreatic response stimulated by secretin and caerulein. The drug could be employed in the treatment of pancreatic insufficiency to obtain a better utilization of pancreatic enzyme supplement. It is questionable whether such long-term therapy may be responsible for the appearance or the relapse of a peptic ulcer.