COMPLETE AMINO ACID SEQUENCE OF A NEW TYPE OF NEUROTOXIN FROM THE VENOM OF THE SPIDER, AGELENA OPULENTA

31 December 1989

journal article
research article
Published by Biomedical Research Press in Biomedical Research

Vol. 11 (3) , 181-186
https://doi.org/10.2220/biomedres.11.181

Abstract

Agelenin isolated from the venom of the spider Agelena opulenta, blocks neurotransmission at lobster neuromuscular synapses in an irreversible manner. The complete primary structure of agelenin, consisting of a single polypeptide chain of 35 amino acid residues, has been determined. The sequence appears to have no precedent among other known neurotoxins.

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