AUTOLOGOUS MARROW RECOVERY AND SENSITIZATION TO NON-HLA ANTIGENS AFTER HLA-IDENTICAL MARROW TRANSPLANTATION FOR APLASTIC-ANEMIA

  • 1 January 1983
    • journal article
    • research article
    • Vol. 11  (1) , 73-81
Abstract
Patients (175) with severe aplastic anemia were treated by high-dose cyclophosphamide and HLA-A, and -D-identical sibling marrow transplants. Patients (38) rejected their grafts. Of the 38, 4 showed autologous marrow recovery as determined by blood genetic markers. The remarkable feature of 1 case following autologous marrow recovery was the presence of unidirectional proliferative and cytotoxic responses of circulating host lymphocytes to marrow donor lymphocytes in mixed lymphocyte culture and cell-mediated lympholysis. Presumably these responses were the result of in vivo sensitization to those non-HLA antigens for which donor and recipient differed.