Chromosomal Alteration and the Development of Tumors, IX

Publisher Website
Google Scholar
Abstract
Pieces of lung tissue from mice bearing Ehrlich ascites tumors (ELD) (containing 13% polyploid cells) are injected into the peritoneal cavity. The ELD tumors thus developed had 73.4% polyploid cells, while the control ELD tumors had only 11. 0%. The experiments were repeated with another ELD tumor strain, showing similar results. When inoculated, the ELD tumors containing 0.2% polyploid cells into the tail veins, 3 metastatic tumors thus developed had 61.9, 40.4 and 17.9% polyploid cells, respectively, while the control animals had only 0.4%. When injected 100 ELD tumor cells into the brain, liver and under the skin, no increase of such cells was observed in tumors developed after direct inoculation. Although the increase of polyploid ceUs after the intraperitoneal inoculation with small cell dosages of ELD tumors was thought to be due to immuno-selection of polyploid cells by several authors, the results obtained suggested that it is difficult to explain by immunoselection, since no increase of polyploid cells was revealed after direct inoculation of tumor cells into organs.

This publication has 1 reference indexed in Scilit: