THE RESPONSE OF THE ADRENAL CORTEX OF THE RAT TO DIETARY SALT RESTRICTION AND REPLACEMENT1

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Abstract
Effect of a diet low in NaCl, with later replacement of salt, on the adrenal cortex of albino male rats was studied by histological and chemical methods, including content of ascorbic acid and cholesterol. Histological findings were in keeping with studies previously described by other investigators and indicated an increase in the width of the zona glomerulosa and a decrease in lipid droplets. Cholesterol content of the adrenal gland diminished with increased activity, while the ascorbic acid content diminished to a less significant degree. Replacement of dietary salt caused within 24 hours a partial return to a normal appearance and at 48 hours the adrenal cortex appeared practically normal. Cholesterol content increased.