Atomic Force Microscopy Observation of Deoxyribonucleic Acid Stretched and Anchored onto Aluminum Electrodes
- 1 April 1999
- journal article
- Published by IOP Publishing in Japanese Journal of Applied Physics
- Vol. 38 (4R)
- https://doi.org/10.1143/jjap.38.2118
Abstract
We have demonstrated that the electrostatic stretch-and-positioning of Deoxyribonucleic Acid (DNA) is useful for the analysis of a long DNA molecule by means of atomic force microscopy (AFM). Using a pair of aluminum electrodes patterned on a glass plate, DNA molecules were stretched parallel to the field line, and immobilized onto the electrodes. Through AFM observation of avidin-labeled DNA, we confirmed the immobilization of individual DNA molecules, not aggregates.Keywords
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