MODIFICATION OF PULLORUM DISEASE IN THE CHICK BY CERTAIN TRICARBOXYLIC ACID CYCLE INHIBITORS AND INTERMEDIATES

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Abstract
The survival time of chicks infected with Salmonella pullorum was reduced by the administration of fluoroacetate, malonate, arsenite, citrate, and succinate. The prolongation of survival time varied with concentration, time of administration in relation to time of infection, and dosage interval. Greater concentrations of the parasite were found initially in the liver and carcass of fluoroacetate-treated chicks than in the same tissues of the untreated birds. Eventually the blood of the "poisoned" chicks yielded greater numbers of organisms than that of untreated birds.