Prediction of Tumour Progression in Superficial Bladder Carcinoma

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Abstract
In a retrospective study, prognostic factors were analyzed in 45 patients with superficial bladder carcinoma (Tis, Ta, T1) with subsequent progression to invasive (T2, T3, T4) and/or metastatic (M+) disease. Findings are compared with those from a control group of 17 patients with no subsequent invasive or metastatic disease. In a single-parameter analysis the following parameters were significantly associated with a high risk of developing invasive disease: tumor multiplicity; tumor invasion of blood and/or lymph vessels; increasing histological grade and the history of previous surgical treatment. In a multivariate analysis, multifocality, small vessel infiltration and previous treatment/time (TPT factor)were significantly related to the risk of subsequent progression. An arbitrary score system revealed that progression could be predicted significantly in patients with a high score.