ALTERATION BY HISTAMINE-RECEPTOR AGONISTS OF THE RELEASE OF ADRENERGIC TRANSMITTER IN THE ISOLATED PERFUSED RABBIT KIDNEY

  • 1 January 1981
    • journal article
    • research article
    • Vol. 249  (2) , 203-212
Abstract
The effects of histamine and synthetic H1 and H2-receptor agonists on the release of neurotransmitter were studied in the isolated perfused rabbit kidney. The increase in perfusion pressure and the contraction of the venous outflow-superfused rabbit aortic strip were taken as the parameters for the evaluation of the elaboration of neuromediator from the kidney due to periarterial stimulation. Histamine and the specific histamine H1-receptor agonist, 2-(2-thiazolyl)ethylamine, increased but the specific H2-receptor agonists, dimaprit and impromidine, decreased the response to periarterial stimulation without altering that of exogenously applied noradrenaline [norepinephrine]. Prior addition of mepyramine to the medium prevented effect of 2-(2-thiazolyl)ethylamine but decreased the responses produced by histamine when compared with the control values. Prior addition to metiamide to the medium prevented the inhibitory effect of dimaprit and impromidine but potentiated the effect of histamine. Histamine has a presynaptic H2-mediated facilitatory and H2-mediated inhibitory effect on the release of neurotransmitter from adrenergic neurons in the isolated perfused rabbit kidney.