Hydrocarbon fermentation: Kinetics of microbial cell growth

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Abstract
Modeling of microbial growth using nonmiscible substrate is studied when kinetics of substrate dissolution is rate limiting. When the substrate concentration is low, the growth rate is described by an analytical relation that can be identified as a Contois relationship. If the substrate concentration is greater than a critical value Scrit, the potentially useful hydrocarbon S* concentration is described by S* = Scrit/(1 + Scrit/S). A relationship was found between Scrit and the biomass concentration X. When X increased, Scrit decreased. The cell growth rate is related to a relation μ = μm[A(X/Scrit)(1 + Scrit/S) + 1]−1. This model describes the evolution of the growth rate when exponential or linear growth occurs, which is related to physico‐chemical properties and hydrodynamic fermentation conditions. Experimental data to support the model are presented.