Enantioselective reformatsky reaction with ketones. Asymmetric synthesis of β-(tert-hydroxy)esters

Abstract
Optically active β-(tert-hydroxy)esters with good enantiomeric excesses (up to 75% e.e.) are synthesised via enantioselective Reformatsky reaction with ketones in the presence of chiral N,N-dialkylnorephedrine.