Cell Population Kinetics in the Intestine of Continuously Irradiated Mice, Using Double-Labelling Autoradiography
- 1 July 1966
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 28 (3) , 694-+
- https://doi.org/10.2307/3571996
Abstract
A Cl4-, H3-TdR double-labeling method was utilized to study the cell population changes in the epithelium of the ileum in mice continuously irradiated for 5 days at 50, 84, or 176 rads/day. The following conclusions were reached. The duration of DNA synthesis in control animals is 6.4[plus or minus]0.4 hours, and of mitosis, 0.4 hour. No major changes occur in the duration of DNA synthesis or of mitosis at the dose rates tested. The number of cells/crypt is similar in the control and irradiated animals. A large amount of cell death and loss occurs at the dose levels examined. An enhanced cell production in indicated; this is probably effected by an increase in the number of proliferating cells/crypt or by a shortening of the cell cycle or by both.This publication has 5 references indexed in Scilit:
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- A 14C- and 3H-thymidine double labeling technique in the study of cell proliferation in Tradescantia root tipsExperimental Cell Research, 1963
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