Relationship between Misonidazole Toxicity and Core Temperature in C3H Mice

Publisher Website
Google Scholar
Abstract
A single i.p. injection of the radiation sensitizer misonidazole at doses greater than 0.5 mg/g produced a transient hypothermic response in C3H mice. An increase in the acute toxicity of this drug was demonstrated when the animal core temperature was maintained at a normal 35-37.degree. C by placing the mice in a warmed environment immediately following drug injection. The LD50/3 days dose of misonidazole was determined to be 1.48 mg/g for mice allowed to become hypothermic following injection but 0.77 mg/g for mice maintained at a normal core temperature following injection.