CD4+CD25+T Cells Prevent Arthritis Associated withBorreliaVaccination and Infection
- 1 June 2005
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 12 (6) , 786-92
- https://doi.org/10.1128/cdli.12.6.786-792.2005
Abstract
CD4+CD25+T cells are a population of regulatory T cells associated with control of arthritis in anti-interleukin-17 antibody-treatedBorrelia-vaccinated and challenged gamma interferon-deficient mice. Here, we present direct evidence that adoptive transfer of enriched CD4+CD25+T cells from these mice can prevent the development of arthritis inBorrelia-vaccinated and challenged mice. These findings establish a major role for CD4+CD25+T cells in the prevention of arthritis inBorrelia-vaccinated and challenged animals.Keywords
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