Comparative in vitro activity of A-56268

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Abstract
The comparative in vitro activity of A-56268 was studied using 1,006 clinical isolates including streptococci, enterococci, staphylocci,Neisseria gonorrhoeae, Haemophilus influenzae and anaerobes. A-56268 showed activity comparable to that of erythromycin and was more active than josamycin and roxithromycin against erythromycin-sensitive aerobic and facultatively anaerobic gram-positive cocci. A-56268 was the most active macrolide againstClostridium spp. andNeisseria gonorrhoeae. Josamycin was more active than either A-56268 or erythromycin against the anaerobic gram-positive cocci and theBacteroides fragilis group. Staphylococci moderately resistant or resistant to erythromycin (MIC 3.12–50 mg/l) remained susceptible to josamycin but not the other macrolides.