Evidence for the Role of Spinal Cord Systems in Parkinsonʼs Disease-Associated Pain

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Abstract
A patient with Parkinson''s disease had severe levodopa-associated leg pain in a beginning-of-dose and peak-dose pattern. Local anesthetic block of the lumbar sympathetic chain or differential epidural block did not alter the pain. Spain anesthesia abolished the pain. We postulate that levodopa-associated pain in Parkinson''s disease either originates in or is mediated by spinal cord dopaminergic systems.