EFFECT OF CHRONIC ETHANOL ADMINISTRATION ON PHOSPHOLIPID ACYL-GROUPS OF SYNAPTIC PLASMA-MEMBRANE FRACTION ISOLATED FROM GUINEA-PIG BRAIN

  • 1 January 1979
    • journal article
    • research article
    • Vol. 24  (2) , 405-408
Abstract
Chronic alcoholism was induced with a liquid diet containing 5% (wt/vol) ethanol in guinea pigs. There was no apparent change in acyl group composition in the myelin lipids; acyl groups changes were seen in the phosphoglycerides of synaptic plasma membranes (SPM). Acyl group changes are related to a decrease in the proportion of monoenes in both choline and ethanolamine phosphoglycerides and an increase in polyenes (15%) in the ethanolamine phosphoglycerides. The changes seen may be associated with the increased membrane-dependent transport activities seen after chronic ethanol treatment.