SHORT COMMUNICATION: Amino Acid Substitutions Which Alter the Antiviral Activity of Human Interferon-α1on Mouse Cells
- 1 December 1988
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 8 (6) , 779-782
- https://doi.org/10.1089/jir.1988.8.779
Abstract
Human interferon-.alpha.1 (IFN-.alpha.1) is one of only three human (Hu) IFN-.alpha.s having significant antivirual activity on mouse cells. Specific amino acid substitutions in HuIFN-.alpha.1 in the region from amino acids 121 to 136 indicate that this region is critical to the determination of mouse and human cell antiviral activities. Bovine cell activities are relatively unaffected by changes in this region. In particular we have identified the arginine residue at position 125 of human IFN-.alpha.1 as a major mediator of the molecules antiviral activity on mouse cells. Various substitutions in the carboxy-terminal region of human IFN-.alpha.1 are also evaluated and discussed in the context of recently published data.This publication has 12 references indexed in Scilit:
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